Drugs like risks factors for oral-facial clefts

Velickova, Nevenka (2011) Drugs like risks factors for oral-facial clefts. Macedonian Pharmaceutical Bulletin, (57). pp. 147-148. ISSN 1409–8695

Text Farmacevtski bilten Ohrid, 2011.pdf Download (19MB)

Abstract

Background: Oral-facial clefts are birth defects in which the tissues of the mouth or lip don't form properly during fetal development. The causes of these birth defects are not well understood, but believe it may be a combination of genetic (inherited) and environmental factors (such as certain drugs, illnesses, and the use of alcohol or tobacco while a woman is pregnant) - multifactorial inheritance.

Aim: To evaluate the incidence, causes and symptoms of oral facial clefts at the children hospitalized in the children’s ward in Stip.

Methods: After birth, cleft lip and palate are diagnosed by physical exam. Special exposure of their mothers during pregnancy indicates that environmental factors increase the risk of cleft lip and palate.

Results: During the past 10 year children with oral facial clefts are borns in series in the same or closer month in the year. Also we have councluded that every year the number od children with oral-facial clefts growing and they were not associated with any syndrome. Their parents doesn’t have a oral-facial clefts. Children with oral-facial clefts have special problems and complication like feeding difficulties, ear infections and hearing loss.

Conclusion: The obtain results suggest that environmental factors, such as drugs (including several different anti-seizure drugs) and maternal smoking, are risk factors for appearance of oral-facial clefts. Cleft lips and palates not associated with a syndrome are caused by a combination of genetic and environmental factors. Other environmental factors that are suspected of playing a role include infections, maternal alcohol use and deficiency of the B vitamin folic acid.

Item Type:	Article
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Health sciences
Divisions:	Faculty of Medical Science
Depositing User:	Nevenka Velickova
Date Deposited:	27 Nov 2012 08:34
Last Modified:	27 Nov 2012 10:50
URI:	https://eprints.ugd.edu.mk/id/eprint/1493

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