Evrosimovska, Biljana and Dimova, Cena and Popovska, Lidija (2015) Matrix matalloproteinase-8 gene polymorphism in chronic periapical lesions. Contributions Sec. Med. Sci., 36 (2). pp. 217-224. ISSN 0351-3254
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Abstract
Background/Aim: Increased levels of matrix metalloproteinase-8 (MMP-8) have been associated
with risk of developing chronic periapical lesion (CPL). Gene polymorphisms are contributing factors
in the pathogenesis of the inflammation. The aim of this study was to analyze polymorphism in
the gene MMP-8 and its association and influence on clinical manifestation of CPL.
Methods: A total of 240 unrelated Macedonian subjects were included in the present study. Poly- morphism -799 C/T in the gene MMP-8 detected with restriction enzyme BgIII was studied in 120
patients with CPL and 120 controls without any signs of chronic or acute inflammatory process in
the jaw. The amplification of the region of selected gene was made with polymerase chain reactionrestriction
fragment length polymorphism (PCR-RFLP).
Results: Our results showed that there were differences in the allele and genotype frequencies of
the MMP8 -799 C/T polymorphisms between patients with CPL and controls (p < 0.05). Also this
study suggests that MMP-8 polymorphism -799 C/T was a risk for expression of CPL
(OR=8.27<3.44<OR<20.26).
Conclusion: The detection of this genetic polymorphism is relevant for obtaining providential
treatment of patients who are at high risk of chronic periapical inflammation.
Key words: chronic periapical lesion, single nucleotide polymorphism, matrix metalloproteinase-8
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Cena Dimova |
| Date Deposited: | 21 Dec 2015 14:00 |
| Last Modified: | 21 Dec 2015 14:00 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/14644 |
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