Milenkovic, Tatjana and Smokovski, Ivica and Kulumova, Elena and Stojanovski, Nikola and Aleksov, Branko (2009) Significant Improvements in Glycaemic Control with BIAsp 30 in Clinical Reality: Experience from Clinical Practice in Macedonia. In: ADA Congress 2009, 05-09 June 2009, New Orleans, USA.
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Abstract
This was a prospective, multicenter, 24-week observational study of
the effectiveness and safety of biphasic insulin aspart 30 (BIAsp 30;
NovoMix® 30) in type 1 and type 2 diabetes patients under normal clinical
practice conditions in Macedonia. Results presented are for 2196 patients
from 30 diabetes centers (41.2% male; mean age 59.6±11.1 y; type 2
diabetes 95.7%; diabetes’ duration 9.0±6.7 y; BMI 28.0±4.5 kg/m2)
inadequately controlled on prior treatment (46.7% with OAD; 48.7%
with insulin).
Most patients (89.3%) were initiated with and completed the study
(86.7%) on twice-daily BIAsp 30. Baseline and 24-wk total daily insulin
doses (U/day) were 39.8±13.8 and 45.8±14.0, respectively. At 24 weeks,
mean HbA1c and 8-point PG profile were significantly improved vs.
baseline. The proportion of patients achieving target HbA1c <7% increased
from baseline (3.9% vs. 31.8% at wk 24). Mean weight was not
significantly increased from 76.4±12.8 kg at baseline to 76.7±12.5 kg at
wk 24. No episodes of major hypoglycemia were reported, and no other
safety issues were raised during the study treatment.
This study provides supportive evidence on the role of BIAsp 30 in the
treatment of diabetes mellitus in routine clinical practice. Further dose
optimization is necessary to increase the number of patients achieving
target HbA1c.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Subjects: | Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Ivica Smokovski |
| Date Deposited: | 28 Dec 2015 13:03 |
| Last Modified: | 28 Dec 2015 13:03 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/14628 |
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