Differences in hematology and biochemical parameters in diabetic patients

Gruev, Todor and Janikevik Ivanovska, Danijela and Jovcevska-Mecevska, Jasmina and Dimitrov, Saso (2011) Differences in hematology and biochemical parameters in diabetic patients. In: IFCC - Worldlab Berlin 2011, 15-19 May 2011, Berlin, Germany.

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Background. This study related to investigated differences in hematology and biochemical parameters in patients with Diabetes Mellitus( type1 and Diabetic Retinopathy and type 2).A direct relation between platelet dysfunction and the development of diabetic complication has yet to be established. Some studies have suggested that the enhanced activation of circulating platelets is particularly apparent in diabetics with microvascular disease.

Methods. In This study was investigated hematological and biochemical parameters in differences between two type of diabetes(type1 N=160;type 1 and Diabetic Retinopathy,N=48 and type 2 N=180) in relation to a control population. Hematological parameters was analyzed In K3EDTA blood used hematological analyzer Sysmex KX-21. The concentration of glucose, HbA1C,Total cholesterol, TG, HDL,VLDL and LDL was determined in Cobas Integra 700 analyzer. The Proptrombin time and fibrinogen concentration are measured in BFTII analyzer.

Results. Our results showed an increased in hematocrit, leucocyte, lymphocyte and monocyte number in diabetic patients, while MCV,MCH(affected of the glucose concentration) and neutrophyls number are decrease. Patients with type 1 diabetes showed an increase in erythrocytes, Hct, leucocytes, lymphocytes (p <,0.05) and glucose(p< 0.01) concentration compared with the control. Hematocrit and platelets index (PDW, MPV, P-LCP) are significantly increased (p<0.05) while neutrophils and monocytes are decreased (p<0.05) in patients with type 1 diabetes and AMI in relation with type 2 diabetes.Diabetic patients have significantly higher plasma fibrinogen concentration compared with control group( 4.75+/-0.95 g/Lvs.c.g.3.15+/-1.1 g/L,p< 0.05). Significant elevation in total serum cholesterol and LDL-cholesterol levels is observed in IDDM cases. Increased serum Triglycerides and VLDL-cholesterol levels are not statistically significant. Serum HDL–cholesterol levels are significantly decreased.

Conclusions. Our results suggest that platelet hyperfunction in diabetic patients may by implicated in the athogenesis of diabetic retinopathy. These results established an altered in plateled volume indices in insulin dependent diabetics suggesting that platelets may involve in developing micro and macro vascular complication in patients.

Item Type: Conference or Workshop Item (Poster)
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Danijela Janikevik
Date Deposited: 14 Dec 2015 14:14
Last Modified: 21 Dec 2015 09:12
URI: https://eprints.ugd.edu.mk/id/eprint/14455

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