Sexual Dysfunction as a Side Effect of Hyperprolactinemia in Methadone Maintenance Therapy

Spasovska Trajanovska, Aneta and Vujovic, Viktorija and Ignjatova, Liljana and Janikevik Ivanovska, Danijela and Chibishev, Andon (2013) Sexual Dysfunction as a Side Effect of Hyperprolactinemia in Methadone Maintenance Therapy. Medical archives, 67 (1). pp. 48-50. ISSN 0350-199

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Although endocrine abnormalities are recognized in opiate users, very little is known
about the range of hormones affected, their pathophysiology and their clinical relevance.
Various endocrine abnormalities have been reported in these patients including, increased
prolactin levels and abnormalities in sexual hormone. Path physiological mechanism postulated
does explain these findings including direct action of heroin or methadone at the hypothalamic
pituitary level. The aim of this study was to explore the effects of heroin and methadone maintenance
treatment on the plasma prolactin levels and sexual function. Material and methods: We
evaluated 20 male narcotic addicts maintained of methadone more than 3 years on oral high dose
methadone 60-120 mgr/day. Patients taking neuroleptic therapy were excluded from the study
because neuroleptic-included hyperprolactinemia. We also evaluated group of twenty male heroin
addicts on the street heroin .The prolactin plasma levels were assayed using the chemiluminescent
immunometric essay (CLIA) - high sensitive methods, The normal range of prolactin levels was
1,5-17 ng/ml(53-360 nmol/l) for men and 1,90-25,0 ng/ml for women. The sexual function was
assessed using a Questionnaire: International Index of Erectile Function (IIEF) with 15 items in
four levels of sexual function. The differences between two examination groups were determined
by a student’s t test. The results show that street heroin addicts (55% of them have high level of
prolactin) have significantly higher plasma prolactin levels (p=0,006) then the group of methadone
maintenance patients (only 15% of them have high prolactin level). In our study, when we compared
sexual dysfunction in examination groups in some domains, we did not find statistical significant
results (sexual desire p=0,52 and overall satisfaction p=0,087). But in domains of erectile function
p=0,011 and orgasm function p=0,033 we got statistical significant results. Key words: heroin
addiction, methadone maintenance therapy, sexual dysfunction, prolactin plasma levels

Item Type: Article
Subjects: Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Medical Science
Depositing User: Danijela Janikevik
Date Deposited: 10 Dec 2015 11:34
Last Modified: 12 Mar 2019 11:26

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