Clinical Relevance of Biomarkers of Oxidative Stress

Frijhoff, Jeroen and Winyard, Paul G. and Zarkovic, Neven and Davies, Sean S. and Stocker, Roland and Cheng, David and Knight, Annie R. and Louise Taylor, Emma and Oettrich, Jeannette and Ruskovska, Tatjana and Cipak Gasparovic, Ana and Cuadrado, Antonio and Weber, Daniela and Enghusen Poulsen, Henrik and Grune, Tilman and Schmidt, Harald H.H.W. and Ghezzi, Pietro (2015) Clinical Relevance of Biomarkers of Oxidative Stress. Antioxidants & Redox Signaling, 23 (14). pp. 1144-1170. ISSN 1523-0864

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Significance: Oxidative stress is considered to be an important component of various diseases. A vast number of
methods have been developed and used in virtually all diseases to measure the extent and nature of oxidative stress,
ranging from oxidation of DNA to proteins, lipids, and free amino acids. Recent Advances: An increased understanding
of the biology behind diseases and redox biology has led to more specific and sensitive tools to measure
oxidative stress markers, which are very diverse and sometimes very low in abundance. Critical Issues: The
literature is very heterogeneous. It is often difficult to draw general conclusions on the significance of oxidative
stress biomarkers, as only in a limited proportion of diseases have a range of different biomarkers been used, and
different biomarkers have been used to study different diseases. In addition, biomarkers are often measured using
nonspecific methods, while specific methodologies are often too sophisticated or laborious for routine clinical use.
Future Directions: Several markers of oxidative stress still represent a viable biomarker opportunity for clinical
use. However, positive findings with currently used biomarkers still need to be validated in larger sample sizes and
compared with current clinical standards to establish them as clinical diagnostics. It is important to realize that
oxidative stress is a nuanced phenomenon that is difficult to characterize, and one biomarker is not necessarily
better than others. The vast diversity in oxidative stress between diseases and conditions has to be taken into
account when selecting the most appropriate biomarker.

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Medical Science
Depositing User: Tatjana Ruskovska
Date Deposited: 10 Dec 2015 10:38
Last Modified: 10 Dec 2015 10:38

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