Drakalska, Elena and Momekova, Denitsa and Rangelov, Stanislav and Lambov, Nikolay (2015) Nanoparticles as platforms for delivery of curcumin. Pharmacia, 62 (2). pp. 50-57. ISSN 0428-0296
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Abstract
Curcumin, the active polyphenol isolated from Curcuma Longa, exhibited potent pleiotropic,
antineoplastic activity, attributed with minimal toxicity to normal cells. Unfortunately,
the clinical implementation of curcumin is limited due to its instability in physiological pH, low
aqueous solubility (11 ng/ml) associated with extremely low systemic bioavailability after oral
administration of 8 g/day. An intriguing approach to overcome these limitations is incorporation
of curcumin in nanoparticles as delivery platforms such as solid lipid nanoparticles, nanoemulsions,
liposomes and macrocyclic cavitands. A promising strategy for improvement of unfavorable
physicochemical characteristics of curcumin consisting of its simultaneous loading in the
phospholipid bilayer membrane and in the aqueous cavity of liposomes as inclusion complex with
macrocyclic cavitands is presented.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Elena Drakalska |
| Date Deposited: | 14 Aug 2015 10:41 |
| Last Modified: | 14 Aug 2015 10:41 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/13690 |
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