Kostik, Vesna and Gjorgjeska, Biljana and Petkovska, Sofija (2015) A Simple Method for Determination of Chloropyramine in Tablets. Advances in Analytical Chemistry, 5 (3). pp. 56-60. ISSN 2163-2847
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Abstract
A simple gas chromatography method with mass detection (GC-MS) for the determination of chloropyramine active pharmaceutical ingredient (API) in tablets was developed. Chromatographic separation was achieved on a fused silica ZB-5 capillary column (30 m x 0.25 mm i.d. x 0.25 μm film thickness). Acquisition was performed in selected ion monitoring mode (SIM) with target ion (58 m/z) and reference ions (71 m/z, 125 m/z). The method was validated in respect system suitability, specificity, linearity, range accuracy and precision, limit of detection (LOD), limit of quantification (LOQ), specificity, robustness and stability. The advantages of this method include simple sample treatment, short elution time (less than 15 min) and short analysis time (less than 25 min). The proposed method could be applicable for routine analysis in pharmaceutical analytical laboratories.
Keywords Active pharmaceutical ingredient, Chloropyramine, Gas chromatography-mass detection, Tablets
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Vesna Kostik |
| Date Deposited: | 14 Aug 2015 10:56 |
| Last Modified: | 14 Aug 2015 10:56 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/13649 |
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