Correlation of Serum Adiponectin and Leptin Concentrations with Anthropometric Parameters in Newborns

Palcevska-Kocevska, Snezana and Aluloska, Natasa and Krstevska, Marija and Shukarova- Angelovska, Elena and Kojik, Ljiljana and Zisovska, Elizabeta and Kocevski, Dragoslav and Kocova, Mirjana (2012) Correlation of Serum Adiponectin and Leptin Concentrations with Anthropometric Parameters in Newborns. Srpski Arhiv Celokupnog Lekarstva, 140 (9-10). pp. 595-599. ISSN 0370-8179

Text Correlation of Serum Adiponectin and Leptin Concentrations with Anthropometric Parameters in Newborns.pdf Download (226kB)

Abstract

Introduction It has been shown that some adipocytokines and their mutual relationship can be indicators
of fetal and neonatal growth. Physiological role of leptin and adiponectin in fetal and neonatal growth
is not well established.
Objectives The aim of this study was to assess the correlation of the anthropometrics parameters and
serum concentration of leptin and adiponectin levels in healthy newborns.
Methods A cohort of 110 neonates, born after uncomplicated singleton pregnancies at term, were
classified as AGA (n=60), SGA (n=30) and LGA (n=20) according to the Lubchenco curves. Anthropometric
parameters of the neonates: birth weight (BW), birth length (BL), body weight/body length ratio (BW/
BL), Body Mass Index (BMI) and Ponderal Index (PI) were recorded after birth.
Results Mean serum leptin and adiponectin levels in both sexes were not significantly different (male:
1.85±0.75; 29.51±22.89 and female: 2.06±0.99; 31.60±23.51 ng/mL). There was a significant difference
between leptin levels in AGA and LGA newborns (1.93±0.84 vs. 3.12±1.50 ng/mL) (p<0.05), and in
adiponectin levels between AGA and LGA compared to SGA newborns (32.8±23.29 and 43.40±31.24 vs.
12.67±2.43 ng/mL, respectivel; p<0.05; p<0.05). Leptin and adiponectin levels were positively correlated
with BW (r=0.63 and r=0.41), BL (r=0.63, r=0.42), BW/BL (r=0.61, r=0.41), BMI (r=0.54, r=0.35), and PI
(r=0.47, r=0.29, (p<0.01).
Conclusion Significantly higher adiponectin levels were found in AGA neonates compared to SGA
neonates. Leptin and adiponectine levels were positively correlated with birth weight. These findings
suggest that these adipocytokines may be involved in fetal growth regulation.
Keywords: leptin; adiponektin; anthropometric parameters; newborn

Item Type:	Article
Subjects:	Medical and Health Sciences > Basic medicine
Divisions:	Faculty of Medical Science
Depositing User:	Elizabeta Zisovska
Date Deposited:	08 Jul 2015 09:15
Last Modified:	08 Jul 2015 09:15
URI:	https://eprints.ugd.edu.mk/id/eprint/13590

Actions (login required)

View Item