Kostik, Vesna and Gjorgjeska, Biljana and Petkovska, Sofija (2015) Development and validation of GC-MS method for analysis of chloropyramine hydrochloride in ointments. IOSR Journal of Pharmacy, 5 (5). pp. 55-59. ISSN 2250-3013
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Abstract
A simple, rapid, sensitive, specific, accurate, and reproducible method for the determination of chloropyramine hydrochloride in ointments based on gas chromatography – mass spectrometry detection was developed and validated. Dissolution of chloropyramine hydrochloride in the ointment was performed with 0.5 M HCl. After alkalization with 25% (V/V) NH4OH, chloropyramine base was extracted with chloroform. The method was validated in respect of linearity, specificity, precision, recovery, limit of detection (LOD), limit of quantification (LOQ) and stability. In terms of performances: Recovery 90.0 – 98.7%, LOD 0.04 mg/g, LOQ 0.132 mg/g, specificity, selectivity and precision the proposed method was found suitable for routine analysis.
Keywords: chloropyramine hydrochloride, chloropyramine base, gas chromatography- mass detection, ointment
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Vesna Kostik |
| Date Deposited: | 10 Jun 2015 07:53 |
| Last Modified: | 10 Jun 2015 07:53 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/13264 |
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