Role of humoral mechanisms in etiology of lichen planus

Popovska, Mirjana and Grchevska, Ladislava and Atanasovska-Stojanovska, Aneta and Kapushevska, Biljana and Muratovska, Ilijana and Minovska, Ana and Radojkova-Nikolovska, Vera and Mitik, Kristina (2015) Role of humoral mechanisms in etiology of lichen planus. Contributions. Sec. Med. Sci., 35 (3). pp. 185-194. ISSN 1857-9345

[thumbnail of 23-M_POPOVSKA.pdf]

Download (216kB) | Preview


Aim: To examine the role of IgA, CIC and component C3 as indicators of humoral immune response
in the etiopathogenesis of oral erosive lichen planus (OELP).
Material and method: The study comprised 19 patients with OELP whose samples of blood, saliva
and tissue were obtained after carefully taken medical history and clinical examination. Samples of
oral mucosa were taken from the site of lesion, i.e. exclusively from buccal mucosa (1 cm in width
and length), and from the deep epithelium as well as a segment from the lamina propria.
Determination of immunoglobulins in serum and saliva, and determination of component C3, was
done using the micro-elisa technique by Rook&Cameron, Engvall and Ulman. Determination of CIC
in serum and mixed saliva was done with the PEG (polyethylene glycol) method. Determination of
immunoglobulin A and component C3 in biopsy material was done with direct immunofluorescence.
Results: Levels of immunoglobulin A in serum in OELP during exacerbation were decreased (1.04 ±
0.49 gr/l) and during remission increased (5.92 ± 0.62) in comparison with the control group (p <
0.001). Levels of CIC during exacerbation and remission were increased (p < 0.001), and component
C3 levels were increased in both examined phases in the examined group compared with the control
group (p < 0.05). Deposits of IgA were registered in one (5.88%) patient with OELP and component
C3 was registered in 3 (17.64%) patients.
Conclusion: Changes in IgA values, as well as CIC and component C3, may correlate with changes in
oral mucosa emphasizing the role of humoral immune response in the pathogenesis of oral lichen planus.

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Ana Minovska
Date Deposited: 09 Dec 2015 11:12
Last Modified: 09 Dec 2015 11:12

Actions (login required)

View Item View Item