The Effect of Smoking on Biomarkers of (Anti) oxidant Status

Jansen, Eugene and Beekhof, Piet and Ruskovska, Tatjana (2014) The Effect of Smoking on Biomarkers of (Anti) oxidant Status. Journal of Molecular Biomarkers & Diagnosis. ISSN 2155-9929

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The influence of smoking on the levels of several biomarkers of oxidative stress, antioxidant status and redox
status have been investigated in 48 healthy men with a mean age of 25 y. The biomarkers of oxidative stress are the
reactive oxygen metabolytes (ROM) and the total oxidant status (TOS). The biomarkers for the antioxidant activity
are the biological antioxidant potential (BAP), the ferric reducing ability of plasma (FRAP), the total antioxidant status
(TAS), the assay for the defense against the oxidation by hypochlorous acid (OXY) and uric acid (UA). The total thiol
levels (TTL) have been measured as a biomarker for the redox status.
The average concentration of ROM was 14% higher in smokers compared with non-smokers (p<0.05), whereas
TOS was 4.9% higher (not statistically significant).The average concentrations of BAP, FRAP and TAS decreased
with smoking with 3.6 (p<0.025), 3.6 (non-significant) and 6.1% (p<0.025), respectively. Alsouric acid, the main
antioxidant in serum and a major contributor to the antioxidant status in serum, decreased by 10.6 % (p<0.025) in
smokers. The biomarker of the redox status (TTL) was not influenced by smoking.
From these results, it is concluded that in epidemiological studies the effect of smoking should be taken in
account when using oxidative stress and antioxidant biomarkers.

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Medical Science
Depositing User: Tatjana Ruskovska
Date Deposited: 03 Feb 2015 09:03
Last Modified: 03 Feb 2015 09:03

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