Dysphagia in gastroesophageal reflux disease (GERD)

Grivceva Stardelova, Kalina and Popova Jovanova, Rozalinda and Deriban, Gjorgji and Joksimovic, Nenad and Zdravkovska, Milka (2014) Dysphagia in gastroesophageal reflux disease (GERD). Journal of the Macedonian Medical Association Mac. Med. Review, 68 (1). pp. 40-43. ISSN 0025-1097

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Introduction. Dysphagia is considered an alarm symptom,
raising the question of stricture or malignancy.
We sought to determine the prevalence and severity of
dysphagia and correlation with severity ofgastroesofageal
reflux disease and its response to therapy.
Methods. A total of 642 patients with endoscopically
confirmed erosive esophagitis (Los Angeles grades AD).
Esophagitis was classified as mild (grade A or B)
or severe (grade C or D).
Results. At baseline, of 642 patients 37% had dysphagia,
43% had severe esophagitis, and 35% mild esophagitis
(odds ratio, 1.39; 95% confidence interval, 1.27-1.51,
p<0.001). Dysphagia resolved in 73% of patients after
4 weeks of proton pump inhibitor (PPI) treatment. Resolution of dysphagia was associated with a mean healing rate of 87% acrossall treatments. Seventeen percent of patients reported persistent dysphagia, and in these patients the healing rates were decreased significantly (mean 72%; p<0.0001).
Conclusions. Dysphagia is common in patients with
erosive esophagitis but is not a reliable clinical predictor of severe erosive esophagitis. Dysphagia resolved with PPI therapy in most cases, but persistent dysphagia may indicate failed healing.
Key words: Gastroesophageal Reflux Disease (GERD),

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Divisions: Faculty of Medical Science
Depositing User: Milka Zdravkovska
Date Deposited: 05 Sep 2014 12:45
Last Modified: 13 Mar 2015 09:15
URI: https://eprints.ugd.edu.mk/id/eprint/10897

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