Preliminary study on screening the intermolecular interactions of organic cation drugs from BSC Class III (case study Metformin)

Cvetkovski, Aleksandar and Gjorgieva Ackova, Darinka and Smilkov, Katarina (2018) Preliminary study on screening the intermolecular interactions of organic cation drugs from BSC Class III (case study Metformin). In: CA16205, F2F meeting, UNGAP WGs, 8-9 March 2018, Leuven, Belgium.

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Abstract

Among the orally administered drugs, about 40% share the properties of organic cations (protonated bases) or neutral bases at physiological pH, which indicates one important point for studying their transport mechanisms [1]. Antineoplastic platinum compounds [2,3], the histamine H2 receptor antagonist cimetidine [4], the antiviral drugs (acyclovir, gancyclovir, lamivudine and zalcitabine) [5-7], the antidiabetic drug metformin [8,9], and the antiarrhythmic drug quinidine [10], are the identified to be transported by the organic cation transporters OCT1, OCT2 and OCT3 (membrane transporters) [2]. The case study of drug model (DM) metformin (MET), that according to Biopharmaceutical Classification System (BCS) belongs to the class III drugs (high solubility, low permeability) [11], emphasizes the importance of non-covalent interactions of this dication drug with range of ligands selected from the GRAS (Generally Recognized as Safe by FDA for food additives list) [12].Comparable study on predicting ligands for OTC1 by docking, applying High-Throughput Screening (HTS) and in silico modeling [15], offer an opportunity for growing the molecular crystals of MET with drugs, that are uses in combo- therapy with MET, as well with excipients and food ingredients, thus by generating the crystallographic, thermodynamic and spectroscopy data MET-ligand interactions, contributes the development of delivery systems with enhanced permeability of BSC class III drug models.

Item Type: Conference or Workshop Item (Poster)
Subjects: Medical and Health Sciences > Other medical sciences
Natural sciences > Other natural sciences
Divisions: Faculty of Medical Science
Depositing User: Darinka Gorgieva Ackova
Date Deposited: 16 Oct 2018 10:01
Last Modified: 16 Oct 2018 10:01
URI: http://eprints.ugd.edu.mk/id/eprint/20566

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