Evaluation of the redox interaction of rutin with some medicinal substances by cyclic voltammetry

Aleksandrov, Mihail and Maksimova, Viktorija and Gulaboski, Rubin (2017) Evaluation of the redox interaction of rutin with some medicinal substances by cyclic voltammetry. In: 17th International Symposium and Summer School on Bioanalysis, 2-8 July 2017, Ohrid, Republic of Macedonia.

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Rutin is one of the most frequently represented flavonoid glycoside found in many plants commonly used in nutrition or herbal preparations. Due to its polyphenolic structure, it could be easily subjected to redox reactions, which allows its analysis by different electrochemical methods. The aim of this study was to evaluate the interactions between rutin and certain medicinal substances, as a potential food-drug interaction, after consuming them in the same time. These interactions can also lead to some synergistic or antagonistic physiological effects. The interactions between rutin and lorazepam, diazepam, alfalipoic acid, glimepiride, acetylsalicylic acid and ascorbic acid, have been evaluated by application of an electrochemical analysis by the means of cyclic voltammetry. The experiments have been performed on a glassy carbon electrode as working electrode and potential range from -0.4 to 0.6 V. The obtained results were used further for calculation of the kinetic of these reactions by implementing the characteristic parameters from cyclic voltammograms in a specially designed theoretical models. The estimated values of the chemical rate constants for the interactions between rutin and the investigated compounds read (in mol-1 L s-1): 0.0025, 0.0022; 0.0024; 0.0020; 0.0550 and 0.0620 for lorazepam, diazepam, lipoic acid, glimepiride, acetylsalicylic acid and ascorbic acid, respectively. From the obtained results, we can conclude that the highest interaction have been noted between rutin and ascorbic acid. These data can serve into prospecting their in vivo interactions.

Item Type: Conference or Workshop Item (Poster)
Subjects: Natural sciences > Chemical sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Viktorija Maksimova
Date Deposited: 18 Oct 2017 09:24
Last Modified: 18 Oct 2017 09:24
URI: http://eprints.ugd.edu.mk/id/eprint/18278

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