Inadequate antioxidant protection in preterm babies: possible cause for hyperbilirubinemia

Gurzanova Durnev, Liljana and Djosic Markovska, Bozidarka and Zisovska, Elizabeta and Zivkovic, Jadranka and Stafilov, Trajče and Zendelovska, Dragica (2011) Inadequate antioxidant protection in preterm babies: possible cause for hyperbilirubinemia. Biologia Macedonia (62). pp. 55-64. ISSN 1857-5277

Inadequate Antioxidant Protection in Preterm Babies Possible Cause for Hyperbilirubinemia.pdf

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Many illnesses in pre-term infants are thought to be related to the action of reactive oxygen species and it is conceivable that the oxidants play a certain role in the etiopathogenesis of unconjugated hy- perbilirubinemia. We hypothesized that an important factor in the mechanism of oxidative injury in hyperbilirubinemic infants on the first day of life would be increased oxidative stress in relation to antioxidants. For this aim, 43 pre-term infants as well as full-term healthy reference group (A=50) were subjected in the present study. Additionally, pre-terms were divided in: healthy pre-terms (B=25) and hyperbilirubinemic pre-terms (C=18). Perinatal variables (gestational age, birth weight and Apgar score) were recorded, and erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity and selenium (Se) levels were measured in umbilical cord blood, immediately after the delivery. The obtained results indicate strikingly lower antioxidant capacity of pre-term infants; they showed significantly lower SOD and GPx activity and Se level, compared to the full-term infants (p<0,001, for all). In the hyperbilirubinemic group, GPx activity and Se levels were found to be significantly lower than those in healthy pre-terms (p<0.001, for both), while SOD showed highly increased enzyme activity (p<0.001). Alterations in enzyme activities were accompanied by a simultaneous significant increase in the bilirubin level (p<0.001). In conclusion, disequilibrium between SOD and GPx activity ratio may represent a marker of oxidative stress in cells of premature infants. Aditionally, this inadequacy of the protection, may cause erythrocyte haemolysis, resulting with hyperbilirubinaemia.

Item Type: Article
Subjects: Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Medical Science
Depositing User: Elizabeta Zisovska
Date Deposited: 11 Aug 2015 09:15
Last Modified: 12 Sep 2016 10:27

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