Gulaboski, Rubin and Scholz, Fritz (2003) Lipophilicity of Peptide Anions: An Experimental Data Set for Lipophilicity Calculations. The Journal of Physical Chemistry B, 107 (23). pp. 5650-5657. ISSN 1520-6106
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Abstract
For the first time, the standard Gibbs energies of the transfer of peptide anions from aqueous solution to
nitrobenzene were determined with the help of electrochemical measurements. These systematic studies clearly
show that the lipohilicity contributions of single amino acid residues to the overall lipohilicity of a peptide
anion strongly depend on the position of the amino acid in the backbone of the peptide. Therefore, additive
models to calculate the overall lipophilicity of a peptide cannot provide very precise data. The present study
is a plea for the experimental establishment of a data set that takes into account the individual nature of an
amino acid residue and its position in a peptide.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ion transfer, peptides, anions, liquid liquid interface, drug design, themrodynamics of ion transfer, voltammetry |
| Subjects: | Medical and Health Sciences > Basic medicine Natural sciences > Biological sciences Natural sciences > Chemical sciences Natural sciences > Physical sciences |
| Divisions: | Faculty of Agriculture |
| Depositing User: | Rubin Gulaboski |
| Date Deposited: | 31 Oct 2012 13:16 |
| Last Modified: | 31 Oct 2012 13:16 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/165 |
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