Bouchard, Géraldine and Galland, Alexandra and Carrupt, Pierre-Alain and Gulaboski, Rubin and Mirceski, Valentin and Scholz, Fritz and Girault, Hubert H. (2003) Standard partition coefficients of anionic drugs in the n-octanol/water system determined by voltammetry at three-phase electrodes. Physical Chemistry Chemical Physics, 5 (17). p. 3748. ISSN 1463-9076
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Abstract
The anionic forms of 26 drugs and organic model compounds have been extensively explored in the n-octanol/
water system using voltammetry at three-phase electrodes. The objective of this study was to validate the ability
of this electrochemical system to give reliable values of lipophilicity for organic ions, as well as to gain more
information on the lipophilic behaviour of anions in the n-octanol/water system. Results were used to clarify
the solvation mechanisms responsible for ion partitioning and to compare the information obtained in the
two solvent systems n-octanol/water and 1,2-dichloroethane/water.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ionizable drugs, ion transfer, octanol, liquid-liquid interface, biomimetic membranes, standard Gibbs energy of ion transfer, drug design |
| Subjects: | Medical and Health Sciences > Basic medicine Natural sciences > Biological sciences Natural sciences > Chemical sciences Natural sciences > Physical sciences |
| Divisions: | Faculty of Agriculture |
| Depositing User: | Rubin Gulaboski |
| Date Deposited: | 31 Oct 2012 13:15 |
| Last Modified: | 05 Nov 2012 11:09 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/161 |
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