Preparation and characterization of liposomal-pegilated calix[4]arenes nanoparticles as drug delivery systems for curcumin

Drakalska, Elena and Momekova, Denitsa and Antonov, Liudmil and Budurova, Desislava and Lambov, Nikolay and Rangelov, Stanislav (2013) Preparation and characterization of liposomal-pegilated calix[4]arenes nanoparticles as drug delivery systems for curcumin. In: 27th Conference of the European Colloid and Interface Society, 1-6 Sept 2013, Sofia, Bulgaria.

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Abstract

Curcumin, the constituent of Curcuma longa, is considered a very promising anticancer agent due to its potent and pleiotropic antineoplastic activity and low nonspecific toxicity to normal cells (1). However the clinical realization of its potential has been limited due to its poor aqueous solubility (11ng/ml) and very low systemic bioavailability. A possible aproach to overcome these limitations is the design of nanosized vechicles of curcumin. The present work reports the preparation, characterization and in vitro evaluation of antineoplastic activity of curcumin loaded calixarenes-in liposomes nanoparticles.

Item Type: Conference or Workshop Item (Poster)
Subjects: Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Elena Drakalska
Date Deposited: 08 Apr 2015 12:42
Last Modified: 08 Apr 2015 12:42
URI: http://eprints.ugd.edu.mk/id/eprint/8254

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