Biological and genotoxic monitoring as integral part of predictive and preventive medical surveillance of children living in polluted area

Velickova, Nevenka and Ruskovska, Tatjana and Kamceva, Gordana and Ivanovska, Verica (2013) Biological and genotoxic monitoring as integral part of predictive and preventive medical surveillance of children living in polluted area. General Medicine Journal, 19 (1-2). pp. 26-30. ISSN 2217-3994

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BIOLOGICAL AND GENOTOXIC MONITORING INTEGRAL PART OF PREDICTIVE AND PREVENTIVE MEDICAL SURVEILLANCE ON CHILDREN WHO LIVE IN POLLUTED AREA(1)_PDF.pdf

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Abstract

Introduction: Presence of many elements and their compounds in the environment pose a significant health risks to the exposed individuals and contributesto the burden of disease in society. An example for one of these black points wich destroyed the health of the people is lead and tine smelter in Veles (city in R of Macedonia). It is obvious that there is environmental-health risk with enough evidence for the pollution of the environment, as well as impact of higher blood level of lead in selected children. Objective: To registred and define the environmental health risk on children in Veles.Method: In this study we compare two groups of 100 children (average 10years old). Exposed group comprised children living in Veles (contaminated area),and control group were children who live in village Ivankovci. Results: Student’s t-test indicates statistically significant differences(t=15.14; p<0.001), between average concentration of lead in the air in Veles (0.94mg/m3) and Ivankovci (0.03 mg/m3); statistically significant differences (t=5.74;p<0.001), between average concentrations of BLL (37.27 μg/ml) in exposed group and control group (18.20 μg/ml); statistically significant differences (t=2.35;p<0.05), between average concentrations of hemoglobin in exposed group (children who live in Veles) and control group and the other hematological parameters between two groups. Discussion: The significance of these results show that children are exposed to mixtures rather than single chemicals. This complexity is a major reason why mixtures are not well studied. In this study are illustrated some of the principles and approaches that can be used to study the effects of mixtures. The multidisciplinary elaboration of the topic, suggests the need for a more serious approach to this important phenomenon(genotoxicological impact of heavy metals) and also is a specific model that is capable of application in other related research. Conclusion: Registered changes had reversible character. Manifested signs of disease were not registered, because of yet successful compensatory mechanisms in the examined children.

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Divisions: Faculty of Medical Science
Depositing User: Nevenka Velickova
Date Deposited: 29 Oct 2013 14:38
Last Modified: 29 Oct 2013 14:38
URI: http://eprints.ugd.edu.mk/id/eprint/7800

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