Synthesis and properties of novel Coenzyme-Q derivatives obtained from Coenzyme Q-0

Naumova, Galaba and Kokoskarova, Pavlinka and Gulaboski, Rubin (2013) Synthesis and properties of novel Coenzyme-Q derivatives obtained from Coenzyme Q-0. In: From Molecules to Functionalized Materials SOE DAAD, Oct 2013, Cluj-Napoca, Romania.

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Coenzyme Q-0 is an amphiphilic compound that is involved in the biosynthesis of Coenzyme Q-10 (CoQ10). CoQ10 transfers electrons along the ETC and protons across the inner mitochondrial membrane (IMM), while taking a crucial part in the oxidative phosphorylation processes. Our goal was to study the possible reaction of CoQ-0 with NaOH, and to learn about the properties of the new derivatives. As main instrumental techniques to achieve the prevised goals we explored voltammetry, UV-vis spectrometry, electron paramagnetic resonance (EPR) nuclear magnetic resonance (NMR), and HPLC MS.1,2 We have found that NaOH can induce cleavage of C-O bond of the metoxy (O-CH3) groups located at positions 2 and 3 on the quinone ring in the structure of Coenzyme Q-0. The newly created products have much stronger antioxidant properties than the native Coenzyme Q-0. Upon reduction, the novel derivatives are strong ligands for Ca2+ and other double charged earth-alkaline cations. The new products obtained via alkaline reaction of Coenzyme Q-0 can be seen as compounds having a double role-antioxidants and metal-ligands. Experiments are in progress aimed to show the effect of the new Coenzyme Q-0 derivatives on living cells.

Item Type: Conference or Workshop Item (Lecture)
Subjects: Medical and Health Sciences > Basic medicine
Natural sciences > Chemical sciences
Divisions: Faculty of Medical Science
Depositing User: Rubin Gulaboski
Date Deposited: 07 Oct 2013 08:20
Last Modified: 07 Aug 2015 07:25

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