Determination of Ketoconazole in Tablets by Using Three Different Methods

Gjorgjeska, Biljana (2012) Determination of Ketoconazole in Tablets by Using Three Different Methods. European Medical, Health and Pharmaceutical Journal, 4. pp. 8-10. ISSN 1804-5804

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Abstract

Ketoconazole has been widely used as an antifungal drug that is formulated as tablets, cream and overthecounter ketoconazole shampoo. The aim of this research was to study and to standardize an ultraviolet spectrophotometric (UVS) method, potentiometric and a high performance liquid chromatographic (HPLC) method for the determination of ketoconazole in commercially available Oromycosal® tablets. These three methods were compared and discussed with respect to their sensitivity, selectivity and readyapplicability in routine analytical work. Absorption spectra and spectrophotometric determinations were carried out on the UVS spectrophotometer. Investigated concentrations were in range from 0.003 to 0.02mg?dm3. The absorbance was measured at 224 nm. In potentiometric titrations glass and saturated (KCl) calomel electrode were used. HPLC analyses of ketoconazole were carried in the presence of econazole as internal standard. It can be concluded that the described methods are simple, fast and reliable for determination of ketoconazole in pharmaceutical preparations. The preparation of the samples is easy, the excipients do not interfere in the methods, so they can be used in routine quality control analysis UDC: 681.2-5 Operation, control, regulation of instruments Key words: assay, ketoconazole, tablets

Item Type: Article
Subjects: Natural sciences > Chemical sciences
Medical and Health Sciences > Health sciences
Divisions: Faculty of Medical Science
Depositing User: Biljana Gorgeska
Date Deposited: 12 Nov 2012 10:13
Last Modified: 12 Nov 2012 10:13
URI: http://eprints.ugd.edu.mk/id/eprint/677

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