Simultaneous determination of polythiazide and prazosin in tablets by second-order derivative UV spectroscopy

Gjorgjeska, Biljana (1991) Simultaneous determination of polythiazide and prazosin in tablets by second-order derivative UV spectroscopy. International Journal of Pharmaceutics, 70. pp. 187-190. ISSN 0378-5173

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Abstract

Abstract A second-derivative spectroscopic method for the simultaneous determination of polythiazide and prazosin in tablets was developed. Solutions of these tablets in 0.2 N methanolic hydrochloric acid were analyzed by measurement of the amplitudes of the positive peak at 356 nm with respect to the negative peak at 346 nm for prazosin, and the amplitude of the positive peak at 236 nm with respect to the baseline for polythiazide. Confirmation of the technique was established using HPLC. The use of derivative spectroscopy in this manner provides a specific, rapid and accurate determination of the binary mixture in the tested concentration range of 1–10 μg/ml for polythiazide and 1–20 μg/ml prazosin. Keywords Polythiazide; Prazosin; Simultaneous determination; Second-derivative UV spectroscopy

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Natural sciences > Biological sciences
Natural sciences > Chemical sciences
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health biotechnology
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Biljana Gorgeska
Date Deposited: 29 Apr 2013 12:28
Last Modified: 03 Jun 2013 07:45
URI: http://eprints.ugd.edu.mk/id/eprint/6180

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