Matrix metalloproteinases

Evrosimovska, Biljana and Dimova, Cena and Velickovski, Boris and Papakoca, Kiro (2011) Matrix metalloproteinases. Revista Romana de Medicina Dentara, 14 (2). pp. 127-139. ISSN 1841-6942

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Abstract

Matrix metalloproteinases (MMPs) are a major group of enzymes that regulate cell–matrix composition. The MMPs are zinc-dependent endopeptidases known for their ability to cleave one or several (extracellular matrix) ECM constituents, as well as nonmatrix proteins. This revue was focused on structural and functional elements of MMPs, and their role in physiological and pathological processes in which it is believed the MMPs play an important, or even indispensable role. According to their structural and functional characteristics, MMPs family members have been classified into six different but closely related subgroups with fairly characteristic but often overlapping substrate specificities. MMP synthesis and functions are regulated by transcriptional activation, post-transcriptional processing (release of pro-domain, cell surface shedding), and control of activity by a family of endogenous inhibitors collectively known as tissue inhibitors of metalloproteinases (TIMPs). The balance of MMPs to TIMPs therefore determines matrix turnover, where either an excess of MMPs or a deficit of TIMPs may result in excess ECM degradation. Moreover, the recent development of selective and non-selective inhibitors of MMPs would also provide new insights in the knowledge of the relationship between activation of inflammatory cells and tissue remodeling and propose new therapeutic possibilities to the treatment of inflammatory disease. Key words: extracellular matrix, matrix metalloproteinases, inflammation

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Cena Dimova
Date Deposited: 01 Apr 2013 11:47
Last Modified: 19 Feb 2014 08:43
URI: http://eprints.ugd.edu.mk/id/eprint/6066

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