Heroin Dependence Duration Influences the Metabolic Parameters Mechanisms and Consequences of Impaired Insulin Sensitivity in Hepatitis C Virus Seronegative Heroin Dependents

Pereska, Zanina and Bozinovska, Cvetanka and Dimitrovski, Chedo and Cakalarovski, Koco and Chibishev, Andon and Zdravkovska, Milka and Babulovska, Aleksandra and Janikevik Ivanovska, Danijela (2012) Heroin Dependence Duration Influences the Metabolic Parameters Mechanisms and Consequences of Impaired Insulin Sensitivity in Hepatitis C Virus Seronegative Heroin Dependents. American Society of Addiction Medicine; J Addict Med, 6 (4). pp. 304-310. ISSN 1935 - 3227

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Abstract

Objective: Carbohydrate metabolism disorder in heroin dependence is an issue with long history and contradicting results. The aim of the study was to evaluate basal insulin sensitivity in hepatitis C virus seronegative heroin dependents with normal body mass index, taking into consideration the duration of heroin dependence. Method: 78 heroin dependents and 32 healthy controls were enrolled in the cross-sectional, prospective study. The dependents were observed in 2 groups: group 1 with dependence duration less than or equal to 3 years and group 2 with more than 3 years. Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and β-cell function (HOMA-B%) were used to define basal glucoseinsulin homeostasis. Results: The group with longer dependence duration had HOMAIR(2.23 ± 3.15) significantly higher compared with the control group (1.23 ± 0.53, P = 0.016) but lower compared with the group with the shorter dependence duration (2.65 ± 2.66, P = 0.024), after adjustment for HOMA-B%, waist circumference, and aspartate aminotransferase. The decrease in HOMA-IR during prolonged heroin addiction was significantly associated with the reduced β-cell function (P < 0.001) and waist circumference (P = 0.004). Conclusions: Heroin dependence is associated with increased insulin resistance in hepatitis C virus seronegative heroin dependents.Prolonged heroin use is associated with reduction of basal β-cell pancreatic function with decreased insulin resistance controlled for waist circumference, but still inducing significantly decreased basal insulin sensitivity. Key Words: dependence duration, heroin, HOMA-B%, HOMA-IR

Item Type: Article
Subjects: Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Medical Science
Depositing User: Milka Zdravkovska
Date Deposited: 23 Jan 2013 08:45
Last Modified: 21 Dec 2015 09:15
URI: http://eprints.ugd.edu.mk/id/eprint/5024

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