Velkoska Nakova, Valentina and Marina, Nada and Krstevska, Branka (2011) Sensitivity and specificity of anti-cyclic citrullinate peptide antibody and IGM rheumatoid factor in serologic diagnosis of rheumatoid arthritis. Macedonian Medical Review, (65):2 (2). pp. 102-105. ISSN 0025-1097
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Abstract
Introduction. In recent years, anti-cyclic citrullinated
peptide (anti-CCP) antibodies have been used as highly
specific and sensitive markers in diagnosis of rheumatoid
arthritis (RA). The aim ot he study was to determine
sensitivity and specificity of anti-CCP antibodies and
IgM rheumatoid factor in patients with RA and their
association with serological markers of disease activity.
Methods. We retrospectively analyzed 60 patients with
RA and 40 without RA (with other rheumatoid disease)
who had attended the Rheumatology Clinic because of
joint pain in the first six months of 2009. The following
parameters were studied: age, sex, disease duration, morning
stiffness, familiar history, erythrocyte sedimentation
rate, haematocrit, number of leucocytes and trombocytes,
CRP, IgM RF, anti-CCP, DAS (disease activity
score) 28, and joint erosion.
Results. Sensitivity and specificity of anti-CCP antibodies
for rheumatoid arthritis diagnosis, based on American
Rheumatoid Association were 66.7% and 95%, respectively.
Sensitivity and specificity for IgM RF were
71.2% and 82.5%, respectively. There was no significant
difference between anti-CCP(+) and anti-CCP(-)
as well as between RF(+) and RF(-) groups for the analyzed
parameters. There was a significant correlation between
anti-CCP and IgM RF (r=0.51, p<0.001) in patients
with RA.
Conclusion. Anti-CCP antibodies are more specific than
IgM RF for diagnosing RA, and may be useful in serologic
diagnosis of RA. There was no difference in disease
activity between anti-CCP(+) and anti-CCP(-) and/
or RF(+) and RF(-) patients with RA.
Key words: rheumatoid arthritis, anti-CCP antibodies,
rheumatoid factor, disease activity join erosion
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Clinical medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Valentina Velkovska |
| Date Deposited: | 17 Dec 2012 14:41 |
| Last Modified: | 17 Dec 2012 14:41 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/3871 |
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