Sensitivity and specificity of anti-cyclic citrullinate peptide antibody and IGM rheumatoid factor in serologic diagnosis of rheumatoid arthritis

Velkoska Nakova, Valentina and Marina, Nada and Krstevska, Branka (2011) Sensitivity and specificity of anti-cyclic citrullinate peptide antibody and IGM rheumatoid factor in serologic diagnosis of rheumatoid arthritis. Macedonian Medical Review, (65):2 (2). pp. 102-105. ISSN 0025-1097

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Abstract

Introduction. In recent years, anti-cyclic citrullinated peptide (anti-CCP) antibodies have been used as highly specific and sensitive markers in diagnosis of rheumatoid arthritis (RA). The aim ot he study was to determine sensitivity and specificity of anti-CCP antibodies and IgM rheumatoid factor in patients with RA and their association with serological markers of disease activity. Methods. We retrospectively analyzed 60 patients with RA and 40 without RA (with other rheumatoid disease) who had attended the Rheumatology Clinic because of joint pain in the first six months of 2009. The following parameters were studied: age, sex, disease duration, morning stiffness, familiar history, erythrocyte sedimentation rate, haematocrit, number of leucocytes and trombocytes, CRP, IgM RF, anti-CCP, DAS (disease activity score) 28, and joint erosion. Results. Sensitivity and specificity of anti-CCP antibodies for rheumatoid arthritis diagnosis, based on American Rheumatoid Association were 66.7% and 95%, respectively. Sensitivity and specificity for IgM RF were 71.2% and 82.5%, respectively. There was no significant difference between anti-CCP(+) and anti-CCP(-) as well as between RF(+) and RF(-) groups for the analyzed parameters. There was a significant correlation between anti-CCP and IgM RF (r=0.51, p<0.001) in patients with RA. Conclusion. Anti-CCP antibodies are more specific than IgM RF for diagnosing RA, and may be useful in serologic diagnosis of RA. There was no difference in disease activity between anti-CCP(+) and anti-CCP(-) and/ or RF(+) and RF(-) patients with RA. Key words: rheumatoid arthritis, anti-CCP antibodies, rheumatoid factor, disease activity join erosion

Item Type: Article
Subjects: Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Medical Science
Depositing User: Valentina Velkovska
Date Deposited: 17 Dec 2012 14:41
Last Modified: 17 Dec 2012 14:41
URI: http://eprints.ugd.edu.mk/id/eprint/3871

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