Correlation of Blood Fibrinolytic Activity and Clinical Outcome After Oral Surgery Interventions

Dimova, Cena and Andonovska, Biljana and Neceva, Violeta and Kovacevska, Ivona and Georgiev, Zlatko (2009) Correlation of Blood Fibrinolytic Activity and Clinical Outcome After Oral Surgery Interventions. Balk J Stom, 13 (2). pp. 111-116. ISSN 107-1141

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The primary aim was to investigate how the oral surgical interventions, as psychophysical and operative trauma, influence the response of the blood fibrinolytic system, and whether the possible changes in the level of the activators and inhibitors of the fibrinolytic system could correlate to clinical results. Fourthly healthy subjects with operative tooth extractions were included in the research; 35 subjects, blood donors, constituted a control group. The influence of the interventions over the parameters of the blood fibrinolytic system was examined prior to surgery and immediately after the extraction with Elisa test. The values of the blood pressure and pulse frequency prior to the surgery; after the applying of the local anaesthesia and immediately after the performed interventions were the only objective parameters for the evident physical reflections of the stress. At the control investigations, after 24, 48, hours and seven days, certain changes like oedema, haematoma, pain and dry socket have been presented. Decreased values of t-Pa and PAI-1 after the oral surgery were found at a high statistically significant difference. The analysis of diastolic blood pressure and pulse frequency values showed statistic significance, showing psychological dimension of oral surgery. There was a positive correlation between most of the parameters from the control examinations and the parameters (t-Pa, PAI-1, pro-activators and inhibitors) of the fibrinolytic system in the examined group. Oral surgical intervention, as a stress factor, had influence and affects the fibrinolytic process through the effect upon pro-activators and inhibitors of the fibrinolytic system, and severity of the clinical outcome after tooth extraction. Parameters of fibrinolytic system, t-PA and PAI-1, can be the most sensitive markers of reaction to oral surgical stress.

Item Type: Article
Subjects: Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Cena Dimova
Date Deposited: 05 Nov 2012 09:56
Last Modified: 30 Sep 2013 11:07

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