Effect of formulation variables on physicochemical characteristics of synbiotic microparticles with Lactobacillus casei

Petreska Ivanovska, Tanja and Petrusevska Tozi, Lidija and Smilkov, Katarina and Popovski, Emil and Grozdanov, Anita and Geskovski, Nikola and Petkovska, Rumenka and Glavas Dodov, Marija and Mladenovska, Kristina (2011) Effect of formulation variables on physicochemical characteristics of synbiotic microparticles with Lactobacillus casei. In: 3rd Pharm Sci Fair: Pharmaceutical Sciences for the Future of Medicines, 13-17 june 2011, Prague, Chech Republic.

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Abstract

Synbiotic microparticles were prepared by spray-drying of aqueous dispersion of alginate, fructooligosaccharide and L.casei, followed by subsequent cross-linking and coating in solution of CaCl2 and chitosan in 1% w/w acetic acid. The aim of the study was to evaluate the influence of the formulation variables in particle size, zeta potential, calcium content and cell entrapment using polynomial regression model at 2nd level. Experimental responese demonstrated dominant influence of the interaction between the concentration of alginate and CaCl2 on all physicochemical parameters of the particles. The concentration of chitosan significantly affected the zeta potential of the particles, while the concentration of alginate was active in determination of the content of Ca 2= in the particles.

Item Type: Conference or Workshop Item (Poster)
Subjects: Natural sciences > Biological sciences
Natural sciences > Chemical sciences
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Katarina Smilkov
Date Deposited: 11 Dec 2012 14:39
Last Modified: 11 Dec 2012 14:39
URI: http://eprints.ugd.edu.mk/id/eprint/3381

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