Association of TNF-a (rs361525 and rs1800629) with susceptibility to cervical intraepithelial lesion and cervical carcinoma in women from Republic of North Macedonia

Duvlis, Sotirija and Dabeski, Drage and Cvetkovski, Aleksandar and Mladenovska, Kristina and Plaseska-Karanfilska, Dijana (2020) Association of TNF-a (rs361525 and rs1800629) with susceptibility to cervical intraepithelial lesion and cervical carcinoma in women from Republic of North Macedonia. The International Journal of Immunogenetics, 47 (6). pp. 522-528. ISSN 1744-313X

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Abstract

Cervical cancer (CCa) is one of the most common malign diseases in women associ-ated with human papillomavirus (HPV). The virus is an initiating factor, but not suf-ficient for the development of cervical intraepithelial lesions (CIN) and CCa. The disease might be a result of the influence of host's genetic factors and polymor-phisms in inflammatory-related genes that modify the immune response to HPV and attribute to cancer susceptibility. We carried out a study to determine the associa-tion between TNF-a-238G/A and TNF-a-308 G/T polymorphisms with HPV-positive CIN and CCa in women living in the Republic of North Macedonia. Using multiplex SNaPshot analysis for single nucleotide polymorphisms (SNPs), we analysed the gen-otype and allele distributions of TNF-a-238G/A and TNF-a-308 G/T in 134 cases (HPV-positive and histologically confirmed CIN and CCa) and in 113 controls (cyto-logical and HPV-negative women). For further analysis, the case group was stratified in three subgroups (all cases: CINs+ CCa− group; CIN2+ -group and CIN1− group). Data analysed using the odds ratio (OR) and chi-square test showed the frequency of AA genotypes and A alleles are not significantly higher in cases compared to the controls for both SNPs: AA of TNF-a-238 (0.7% versus 0%) and TNF-a-308 (1.5% versus 0.9%) as well as A allelic frequency (3.0% versus 1.7%) and (13.1% versus 10.6), respectively. The comparison of the case's subgroups with the control group did not show a statistically significant difference. Compared to controls, TNF-a-238G/A and TNF-a-308 G/T are not associated with the risk of HPV associated CIN or CCa in the studied women.

Item Type:	Article
Impact Factor Value:	1.13
Subjects:	Medical and Health Sciences > Basic medicine Natural sciences > Biological sciences Engineering and Technology > Nano-technology
Divisions:	Faculty of Medical Science
Depositing User:	Aleksandar Cvetkovski
Date Deposited:	13 Nov 2020 09:48
Last Modified:	13 Nov 2020 09:48
URI:	https://eprints.ugd.edu.mk/id/eprint/26724

Available Versions of this Item

• Association of TNF-a (rs361525 and rs1800629) with susceptibility to cervical intraepithelial lesion and cervical carcinoma in women from Republic of North Macedonia. (deposited 10 Nov 2020 09:35)
  • Association of TNF-a (rs361525 and rs1800629) with susceptibility to cervical intraepithelial lesion and cervical carcinoma in women from Republic of North Macedonia. (deposited 13 Nov 2020 09:48) [Currently Displayed]

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