White Fat Progenitor Cells Reside in the Adipose Vasculature

Tang, Wei and Zeve, Daniel and Suh, Jae Myoung and Bosnakovski, Darko and Kyba, Michael and Hammer, Robert E. and Tallquist, Michelle D. and Graff, Jonathan M. (2008) White Fat Progenitor Cells Reside in the Adipose Vasculature. Science, 322. pp. 583-586.

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White adipose (fat) tissues regulate metabolism, reproduction, and life span. Adipocytes form throughout life, with the most marked expansion of the lineage occurring during the postnatal period. Adipocytes develop in coordination with the vasculature, but the identity and location of white adipocyte progenitor cells in vivo are unknown. We used genetically marked mice to isolate proliferating and renewing adipogenic progenitors. We found that most adipocytes descend from a pool of these proliferating progenitors that are already committed, either prenatally or early in postnatal life. These progenitors reside in the mural cell compartment of the adipose vasculature, but not in the vasculature of other tissues. Thus, the adipose vasculature appears to function as a progenitor niche and may provide signals for adipocyte development.

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Natural sciences > Biological sciences
Divisions: Faculty of Medical Science
Depositing User: Darko Bosnakovski
Date Deposited: 30 Nov 2012 14:05
Last Modified: 08 Feb 2013 09:05
URI: http://eprints.ugd.edu.mk/id/eprint/2519

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