Prevalence and Risk Factors for Pre-Diabetes and Diabetes After Kidney Transplantation

Smokovski, Ivica (2017) Prevalence and Risk Factors for Pre-Diabetes and Diabetes After Kidney Transplantation. Physioacta: Journal of Macedonian Association of Physiologists and Anthropologista. ISSN 1857-5587

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Abstract

Post-transplant diabetes mellitus (PTDM) after renal transplantation is main complication that increases overall cardiovascular morbidity and graft survival. Using fasting blood glucose the prevalence of diabetes is underestimated, and it is impossible to assess the existence of pre-diabetes or impaired glucose tolerance (IGT). Material and Methods: In this cross-sectional study we evaluate the prevalence of diabetes and pre-diabetes using oral glucose tolerance test (OGTT), and the impact of potential risk factors associated with their occurrence. 59 patients after renal transplantation from a living donor who were on the same triple immunosuppressive therapy in the maintenance doses, without prior history of diabetes, and without rejection episodes were included in the study. OGTT with 75 grams of anhydrous glucose was performed in all patients with normal or impaired fasting glycaemia (IFG). According to the results, patients were divided into two groups: dysglycemia group (DM, IFG, IFG) and normal group (without glucose disorders). Results: Before OGTT at 13.55% (8/59 patients) was established IFG and 86.44% (51/59 patients) were normoglycemic. After performing OGTT the overall prevalence of glucose disorders (diabetic patients and pre-diabetic) was 33.9% (20/59), and normoglycemic 66.1% (39/59). The prevalence of PTDM, IGT and IFG were 3.39% (2/59) , 30.5% (18/59) 11.86 (7/59) respectively. In the whole group cyclosporine trough level (CsA) (r = 0.37, p <0.05), total lipids TL (r = 0.31, p <0.05), LDL-c (r = 0.28, p <0.05) and the time since transplantation (r = -0.26, p <0.05) were significantly correlated with the postprandial glycemia. In the dysglycemic group CsA trough level (r = 0.38, p <0.05), TL (r = 0.44, p <0.05) and LDL-h (r = 0.51, p <0.05) was significantly associated with the development of glucose disorders. Conclusion: There is a high prevalence of pre-diabetes among renal transplant recipients. Major risk factors for glucose disorder after transplantation are CsA trough levels, and concentrations of total lipids and LDL cholesterol.

Item Type: Article
Subjects: Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Medical Science
Depositing User: Ivica Smokovski
Date Deposited: 08 Jun 2020 06:33
Last Modified: 08 Jun 2020 06:33
URI: http://eprints.ugd.edu.mk/id/eprint/24081

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