Postmenopausal breast cancer: European challenge and innovative concepts

Smokovski, Ivica (2017) Postmenopausal breast cancer: European challenge and innovative concepts. EPMA Journal. ISSN 1878-5085

2017 Ivica Smokovski et al_Postmenopausal BC_EPMA J 2017.pdf

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Breast cancer (BC) epidemic is recognized now worldwide as the reality of the early twenty-first century. Increasing trends in the postmenopausal BC prevalence, even for the European countries earlier demonstrating relatively stable incidence rates of the disease, are highly alarming for the healthcare givers. This new actuality requires a substantial revision of the paradigm currently applied to the BC management and creation of highly innovative concepts. Current multi-centered study highlights new complex mechanisms of the development and progression of the postmenopausal BC. Innovative concepts are presented which argue for more effective predictive and preventive approaches well justified in view of the clusters of the symptoms analysed here and demonstrated as highly prevalent in the postmenopausal breast cancer versus BC-free individuals. Another conceptual novelty presented here is a new interpretation of the Seed and Soil theory of metastasis in BC. According to the new concept, the pre-metastatic niches (Soil) are created by a systemic hypoxia a long time before the breast malignancy is clinically manifested.

Item Type: Article
Impact Factor Value: 4.661
Subjects: Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Medical Science
Depositing User: Ivica Smokovski
Date Deposited: 06 Jun 2020 05:44
Last Modified: 06 Jun 2020 05:44

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