Voltammetry application in measuring kinetics of drug-drug and the enzyme-substrate interactions

Gulaboski, Rubin (2019) Voltammetry application in measuring kinetics of drug-drug and the enzyme-substrate interactions. . (Unpublished)

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Abstract

We present in this work potential applications of voltammetric techniques to get insight into the kinetics of drug-drug interactions, and to kinetics of enzymatic reactions. The-so called catalytic regenerative mechanism is a powerful model to mimic the drug-drug and enzyme-substrate interactions under voltammetric conditions. Various theoretical models on this electrode mechanism provide means to to get access to kinetic and thermodynamic parameters relevant for many drug-drug and enzyme-substrate interactions. While we present plenty of simulated voltammograms, we give the readers simple approaches to access important physical parameters relevant to the chemical reactivity of lipophilic and hydrophilic drugs and enzymes.

Item Type: Teaching Resource
Subjects: Medical and Health Sciences > Basic medicine
Natural sciences > Chemical sciences
Natural sciences > Physical sciences
Divisions: Faculty of Medical Science
Depositing User: Rubin Gulaboski
Date Deposited: 25 Nov 2019 11:20
Last Modified: 25 Nov 2019 11:20
URI: http://eprints.ugd.edu.mk/id/eprint/22941

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