Association of biomarkers of oxidative stress, stress glycaemia and glycated haemoglobin with coronary artery disease

Vavlukis, Marija and Kamceva, Gordana and Kitanoski, Darko and Shehu, Enes and Taravari, Hajber and Pocesta, Bekim and Kedev, Sasko and Georgevska - Ismail, Ljubica (2019) Association of biomarkers of oxidative stress, stress glycaemia and glycated haemoglobin with coronary artery disease. In: Acute Cardiovascular Care 2019, Malaga, Spain .

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Abstract

Introduction: Reactive oxygen species (ROS) are responsible for generalized oxidation which results in cell dysfunction, necrosis or apoptosis. Assessment of oxidative stress markers could modify course of treatment of patients with coronary artery disease (CAD). The aim of this study was to evaluate association of markers of oxidative stress, stress glycaemia and glycated hemoglobin (HgbA1c) with CAD. Methods: Crosssectional observational study. Variables: demographics, risk factors and comorbidities, lipoprotein and glycemic profile, oxidative stress biomarkers: malondialdehyde (MDA) and hydro peroxide (HP), and antioxidant enzymes: superoxide dismutase (SOD), CATALASE and glutathione peroxidase (GPS). Comparison was performed between CAD patients and healthy controls, patients with acute coronary syndrome (ACS) versus chronic CAD, and between PCI revascularised and stable post MI patients. Results: 300 patients, (64.7% m/36.3% f), mean age 62±11 y. (p=ns between genders). 187 (62.3%) were ACS and 113 (37.7%) chronic CAD patients. There was no statistical significant difference in the risk profile between the CAD groups. Patients with CAD had significantly higher prooxidative and significantly lower antioxidative levels of biomarkers (Table 1), as compared with healthy volunteers. Statistically significant differences were observed for HP and SOD between ACS and HCAD group. In HCAD group, revascularized patients demonstrated higher oxidative stress as compared to stable post MI patients. In ACS patients statistical significant intergroup difference was registered, but not pointing to the single type of ACS. ACS patients had also higher levels of stress glycaemia and HgbA1c. Significant positive correlation were found for HgbA1c and stress glycaemia with MDA (r=,154**, p=0,008; r=,254**, p=0,024 respectively). Conclusion: CAD patients demonstrated pronounced oxidative stress when compared to healthy controls, ACS patients had higher oxidative stress as compared with chronic CAD patients, PCI subgroup performed worse that stable post MI patients. Higher oxidative stress activity was linked to worse glycemic control as measured threw stress glycaemia and HbA1c.

Item Type: Conference or Workshop Item (Poster)
Subjects: Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Medical Science
Depositing User: Gordana Kamceva
Date Deposited: 25 Nov 2019 11:17
Last Modified: 25 Nov 2019 11:17
URI: http://eprints.ugd.edu.mk/id/eprint/22936

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