Association between Foetal Growth and Different Maternal Metabolic Characteristics in Women with Gestational Diabetes Mellitus

Krstevska, Branka and Velkoska Nakova, Valentina and Adamova, G. and Simeonova, S. and Dimitrovski, Chedo and Livrinova, Vesna and Serafimoski, V. (2009) Association between Foetal Growth and Different Maternal Metabolic Characteristics in Women with Gestational Diabetes Mellitus. Contributions, Sec. Biol. Med. Sci., XXX (2). pp. 103-114. ISSN 0351–3254

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Abstract

Abstract: Objective: The aim of the study was to investigate the association between foetal growth and different maternal metabolic characteristics in women with gestational diabetes mellitus (GDM). Methods: The study group included 200 consecutive pregnant women who attended the Endocrinology, Diabetes and Metabolic Disorders Outpatient Department in the period from 02.2006 to 02.2009 with singleton pregnancy and GDM diagnosed following ADA criteria. The following parameters were studied: pre-pregnancy maternal body mass index (BMI), 3-hours 100g oral glucose tolerance test (OGTT) results, glycosylated haemoglobin (HbA1c), total lipids (TL), total cholesterol (TH), triglycerides (TG), HDL- and LDL-cholesterol levels at admission. Neonatal birth weight and the prevalence of being large for gestational age (LGA) was an end-point. Results: We found a significant association between birth weight and pre-pregnancy BMI, HDL-C and birth weight of a large child born previously. Birth weight of a large child born previously was the strongest independent predictor for LGA. The prevalence of LGA (from 27% to 80%) was related to a number of altered maternal characteristics. Conclusion: Pre-pregnancy BMI, HDL-C and birth weight of a large child born previously are the independent predictors for LGA, but results of glucose levels during OGTT are not useful in the prediction of LGA in GDM pregnancies. Probably morefactors and other maternal metabolic parameters than glucose levels during OGTT are responsible for the risk of LGA. Key words: gestational diabetes, LGA, macrosomia, maternal characteristics, OGTT.

Item Type: Article
Subjects: Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Medical Science
Depositing User: Valentina Velkovska
Date Deposited: 31 Oct 2012 23:06
Last Modified: 24 Oct 2014 08:02
URI: http://eprints.ugd.edu.mk/id/eprint/227

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