The diagnosis of Daucus Carota as alergogen on the immune system in white laboratory rat

Spasov, Mire and Gjorgoski, Icko (2019) The diagnosis of Daucus Carota as alergogen on the immune system in white laboratory rat. Knowledge - International Journal, Scientific Papers. ISSN 2545-4439


Download (1655Kb) | Preview


The allergic reaction or type I hypersensitivity is a hypersensitive disorder to the immune system, which occurs by ingress of non-pathogenic agents from the external environment in the body. Antigens, in this case allergens, are substances from the environment that are harmless to most people. In allergies there is an inherent tendency to inherit the genes that make these people susceptible to allergies. Rapid sensitization may occur as a local reaction, which is just unpleasant (seasonal rhinitis or hay fever), severe exhaustion (asthma), or culminating in a fatal systemic disorder (anaphylaxis). Allergens in the body are inserted by inhalation, ingestion or injection, and move to mucous membranes, where they are accepted by T-lymphocytes. TN2 lymphocytes produce IL-4, which stimulate B-lymphocytes to differentiate into plasma cells. These cells excrete IgE, which recognize allergens. Excreted IgE antibodies sensitize mast cells that originate from the bone marrow. When sensitized individuals again expose themselves to an allergen from the external environment, they bind to specific IgE-antibodies to the mast cells (memory cells), whereby various mediators are excreted, causing inflammatory response, mucus secretion, vasoconstriction of blood vessels, and spasm of the airways.

Item Type: Article
Subjects: Natural sciences > Biological sciences
Divisions: Faculty of Natural and Technical Sciences
Depositing User: Mire Spasov
Date Deposited: 11 Sep 2019 12:48
Last Modified: 11 Sep 2019 12:48

Actions (login required)

View Item View Item