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Nutrients. 2019 Aug 5;11(8). pii: E1805. doi: 10.3390/nu11081805.

Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability.

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Human Nutrition Unit, Department of Veterinary Science, University of Parma, 43121 Parma, Italy.
Human Nutrition Unit, Department of Food & Drug, University of Parma, 43124 Parma, Italy.
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Laboratory of Food and Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, 30100 Murcia, Spain.
School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G31 2ER, UK.
Laboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
National Research Council (CNR), Institute of Clinical Physiology (IFC), 73100 Lecce, Italy.
Department of Applied Pharmacy, Faculty of Medical Sciences, Goce Delcev University, 2000 Stip, Macedonia.
Biomarkers & Nutrimetabolomic Laboratory, Department of Nutrition, Food Sciences and Gastronomy, XaRTA, INSA, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08921 Santa Coloma de Gramenet, Spain.
CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 08028 Barcelona, Spain.
UCD Institute of Food and Health, University College Dublin, Dublin 4, Ireland.
School of Advanced Studies on Food and Nutrition, University of Parma, Parma, Italy and Microbiome Research Hub, University of Parma, 43124 Parma, Italy.
Université Clermont Auvergne, Institut National de la Recherche Agronomique (INRA), Unité de Nutrition Humaine (UNH), CRNH Auvergne, F-63000 Clermont-Ferrand, France.
Department of Nutritional Sciences, School of Life Course Sciences, Faculty of Life Science and Medicine, King's College London, London SE1 9NH, UK.
Human Nutrition Unit, Department of Food & Drug, University of Parma, 43124 Parma, Italy.


Plant-based diets rich in bioactive compounds such as polyphenols have been shown to positively modulate the risk of cardiometabolic (CM) diseases. The inter-individual variability in the response to these bioactives may affect the findings. This systematic review aimed to summarize findings from existing randomized clinical trials (RCTs) evaluating the effect of hydroxycinnamic acids (HCAs) on markers of CM health in humans. Literature searches were performed in PubMed and the Web of Science. RCTs on acute and chronic supplementation of HCA-rich foods/extracts on CM biomarkers were included. Forty-four RCTs (21 acute and 23 chronic) met inclusion criteria. Comparisons were made between RCTs, including assessments based on population health status. Of the 44 RCTs, only seven performed analyses on a factor exploring inter-individual response to HCA consumption. Results demonstrated that health status is a potentially important effect modifier as RCTs with higher baseline cholesterol, blood pressure and glycaemia demonstrated greater overall effectiveness, which was also found in studies where specific subgroup analyses were performed. Thus, the effect of HCAs on CM risk factors may be greater in individuals at higher CM risk, although future studies in these populations are needed, including those on other potential determinants of inter-individual variability. PROSPERO, registration number CRD42016050790.


artichoke; caffeoylquinic acids; cardiometabolic health; cereals; coffee; dietary supplements; hydroxycinnamic acids; interindividual variability; polyphenols; potato

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