ROS and SOCE: recent advances and controversies in the regulation of STIM and Orai

Bogeski, Ivan and Kilch, Tatiana and Niemeyer, Barbara A. (2012) ROS and SOCE: recent advances and controversies in the regulation of STIM and Orai. The Journal of Physiology, 590 (17). pp. 4193-4200. ISSN 0022-3751

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Store-operated Ca2+ entry (SOCE) is a widespread mechanism in cells to raise cytosolic Ca2+ and to refill Ca2+ stores. T cells critically rely on SOCE mediated by stromal interaction molecules (STIM) and Orai molecules for their activation and regulation of gene transcription; cells such as muscle cells, neurons or melanocytes probably utilize SOCE for the transmission of inducible receptor-mediated function as well as for generalized Ca2+ homeostasis mechanisms. Exposure to environmental or cell-intrinisic reactive oxygen species (ROS) can affect several components involved in Ca2+ homeostasis and thus alter multiple pathways. While all cells have a capacity to produce intracellular ROS, exposure of immune and skin cells to extracellular oxidative stress is particularly high during inflammation and/or with UV exposure. This review briefly summarizes cell-intrinsic sources ofROS and focuses on current findings and controversies regarding the regulation of STIM and Orai by oxidative modifications. We also introduce melanocytes as a new model system to study the function of STIM and Orai isoforms under physiological conditions that include exposure to UV light as an activating stimulus.

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Health biotechnology
Divisions: Faculty of Medical Science
Depositing User: Ivan Bogeski
Date Deposited: 27 Nov 2012 10:47
Last Modified: 07 Oct 2013 09:59

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