Increasing water solubility, the prerequsite for improvement of bioavailability

Cvetkovski, Aleksandar and Drakalska, Elena and Angelovska, Bistra (2018) Increasing water solubility, the prerequsite for improvement of bioavailability. "Acta Medica Balkanica", International Journal of Medical Sciences, 3 (5). pp. 9-12. ISSN 2545-4870


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Many of low water soluble drugs, from the group of small size molecules, once being administered as single therapeutic doses, not oftenmay reach their plasma cyclized derivatives, that play a role as functionalized excipients in pharmaceutical formulations, enhance the drug solubility toward the formation of inclusion complexes by noncolavelt intermolecular interactions between the molecules of CD and drug. The value of the binding affinity constant of inclusion complex formation imply to the stoichiometric ratio of CD and drug in inclusion complex and its water solubility. -CD and anti epileptic drug -CD and CBZ, respectively. Both solid systems are formed by using each of two polymorphic form of CBZ, form I and form III, respectively. The dissolution profiles, gained by performing the test for the Intrinsic Dissolution rate (IDR), and contributes by the thermodynamic data from the thermal analyses, -CD and HPMC influence the phase transition of metastable CBZ form I to stable CBZ form III. Though the CBZ form I exert higher water solubility then CBZ form III, both polymorphic forms in water medium undergo to transformation in CBZ dehydrate, that water solubility is lower comparing to solubility of a both anhydrous CBZ polymorphs.

Item Type: Article
Subjects: Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Elena Drakalska
Date Deposited: 23 Apr 2019 12:35
Last Modified: 23 Apr 2019 12:35

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