Detecting Heavy Metals Associated Genotoxicity in Plant Model Systems

Gjorgieva Ackova, Darinka (2012) Detecting Heavy Metals Associated Genotoxicity in Plant Model Systems. In: COST Action CM1106: Chemical Approaches to Targeting Drug Resistence in Cancer Stem Cells, 1st Workshop, 3-5 July 2012, Milano-Universita degli Studi di Milano, Italy.

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In this study we evaluated the application of Random Amplified Polymorphic DNA (RAPD) as molecular marker to detect DNA damage in plant model systems caused by environmental pollutants as heavy metals are.Results showed that RAPD-PCR technique is a powerful tool for screening DNA damage induced by non-lethal levels of organic and inorganic contaminants. A further consideration is that changes in the DNA fingerprints obtained may be used to identify target genes for particular genotoxic agents; this will open up possibilities of designing specific assays for detection of specific agents and may help explain the presence in the genome of preferential mutation points.

Item Type: Conference or Workshop Item (Poster)
Subjects: Medical and Health Sciences > Basic medicine
Divisions: Faculty of Medical Science
Depositing User: Darinka Gorgieva Ackova
Date Deposited: 26 Nov 2012 14:01
Last Modified: 06 Mar 2018 10:45

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