Anti-caries vaccine - approach and challenges

Todorov , Strahil and Gjorgieva Ackova, Darinka and Smilkov, Katarina (2018) Anti-caries vaccine - approach and challenges. In: Digital vs Analogical in Dental Medicine- First International Students Congress in Dental Medicine - 2018, 28-29 March 2018, Stip, Macedonia.

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Dental caries is the most common bacterial infectious disease in human and has become the basic cause of oral discommode and tooth damage, seriously touching the quality of life of the patients. It is induced by specific class of acid-producing bac¬terias (e.g., Streptococcus mutans). S. mutans has been strongly concerned as the prominent pathogen of dental caries in human. Anti-caries DNA vaccination is a new immunization procedure against dental infectious disease, and has many preferences over traditional vaccines, such as easy proceeding and contribution, and induction of long-lasting cellular and humoral immune responses. Anti-caries DNA vaccine may act as a multi-epitope vaccine and elevate strong immune response targeting S. mutans associ¬ated antigens. Anti-caries DNA vaccine can induce S-IgA antibod¬ies against S. mutans, decrease adherence and biofilms disposition, reducing the frequency of dental caries as a result. As a disadvantage, this vac¬cine has low immunogenicity because of its low capability for uptake. As innovative approach, dental vaccines for prophylactic immunization can be the first non-living vaccines to be applied by mucosal route during the first three years of life. Further understanding and investigations of the signals that control the colonization and growth of S. mutans in dental biofilms may help to reduce spread and detrimental effects of cariogenic bacteria.

Item Type: Conference or Workshop Item (Poster)
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Darinka Gorgieva Ackova
Date Deposited: 01 Feb 2019 10:07
Last Modified: 01 Feb 2019 10:07

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