Efficacy of intraperitoneal bupivacaine on pain relief after laparoscopic cholecystectomy

Toleska, Marija and Kartalov, Andrijan and Kuzmanovska, Biljana and Panovski, Milcho and Shosholcheva, Mirjana and Dimitrovski, Aleksandar and Cholanchevski, Risto and Toleska, Natasha and Zdravkovska, Milka (2018) Efficacy of intraperitoneal bupivacaine on pain relief after laparoscopic cholecystectomy. Contributions. Sec. Med. Sci., 39 (1). pp. 123-129. ISSN 1857-9345

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Abstract

Introduction: Patients undergoing laparoscopic cholecystectomy do experience postoperative pain, especially in the abdomen. Postoperative pain management remains a major challenge after laparoscopic procedures. Administration of intraperitoneal local anesthetic (IPLA) after surgery is used as a method of reducing postoperative pain. In this study, we evaluated the effect of intraperitoneal infiltration of local anesthetic (bupivacaine) for pain relief after laparoscopic cholecystectomy. Material and methods: In this prospective, controlled, and randomized study were included 50 patients aged 25-60 years (35 female and 15 male), scheduled to laparoscopic cholecystectomy with ASA classification 1 and 2. Patients were classified randomly into two groups: group A, which included 25 patients who received intraperitoneal instillation of bupivacaine 0.5% 20 ml; and group B, which included 25 patients who didn’t receive any intraperitoneal instillation. Postoperative pain was recorded using the visual analogue scale (VAS) for 24 hours after laparoscopic cholecystectomy. Results: There was no significant difference with respect to age, weight, and sex; duration of surgery; and anesthesia time. VAS scores at different time intervals were statistically significantly lower at all times in group A compared to group B. There were statistically significant differences in VAS scores between group A and group B at all postoperative time points - 1hr,4 hr,8 hr,12hr and 24hr (p < 0.00001). Conclusion: Intraperitoneal instillation of bupivacaine provides good analgesia in the postoperative period after laparoscopic cholecystectomy. Keywords: laparoscopic cholecystectomy, intraperitoneal instillation, bupivacaine

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Divisions: Faculty of Medical Science
Depositing User: Milka Zdravkovska
Date Deposited: 01 Feb 2019 10:07
Last Modified: 20 Aug 2019 12:52
URI: http://eprints.ugd.edu.mk/id/eprint/21237

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