Monitoring of renal function in patients with Medication-overuse headache (MOH)

Yzeiri Havziu, Drita and Gjorgjeska, Biljana and Cvetkovska, Dragana and Bilali, Sefedin and Nikolov, Igor (2018) Monitoring of renal function in patients with Medication-overuse headache (MOH). In: 3rd International Scientific Conference of the Faculty of Medical Science, 8-10 Nov 2018, Ohrid, Macedonija.

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Excessive drug use - Medication-overuse headache (MOH) can be result of chronic daily headaches, where headaches occur 15 or more days a month, when the therapeutic agent is used excessively and regularly for more than three months. A recent studies concern the epidemiology of drug-induced disorders suggest that increased risk of nephrotoxicity appear in a particular group of patients who abuse NSAIDs. The aim of this work is to confirm the early phase of nephrotoxicity in patients with (MHO). Our plan is to have two groups of MHO patients, in the first group would be users of non-steroidal anti-inflammatory drugs (NSAIDs) and in the second group the patients that use combinations of various analgetics. Besides conventional markers of renal functioning (serum/urine creatinine determined by Jaffe methods, enzymatic assay for urea serum and GFR by Cockcroft Gaunt formula), we will use colorimetric method for determine N-acetyl–β-d-glucosaminidase–NAG and kinetic assay for Alanin Aminopeptidase-AAP in urine, IFCC for Gamma-glutamyltransferase-GGT. Imunoturbodimetric assay for determination of urinary albumin, microalbuminuria and α1-microglobulin will be used. From the proposed trials and the expected results, we will have an overview of the real state of functioning of the kidneys in patients with MHO. We would like to prove that the nephrotoxicity caused by NSAIDs could be detected by monitoring certain biomarkers quite early. This is a very important prerequisite to overcome the nephrotoxic effect. Taking into account that nephrotoxicity is a reversible process, the early identification can prevent the development of more serious renal diseases and the number of renal patients due to nephrotoxicity of NSAIDs can be reduced.

Item Type: Conference or Workshop Item (Lecture)
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Biljana Gorgeska
Date Deposited: 28 Nov 2018 11:13
Last Modified: 28 Nov 2018 11:13

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