Adverse drug interactions in dental practice

Darkovska-Serafimovska, Marija (2018) Adverse drug interactions in dental practice. In: Digital vs analogical in dental medicine, 28-29 March 2018, Stip, Macedonia. (Unpublished)


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Introduction: Rapid advancement in dental pharmacotherapy requires clinicians constantly to update their knowledge of drug-interactions. Adrenergic vasoconstrictors are used by dentists to increase the activity of local anaesthetics and to control local bleeding. Although commonly considered safe for these applications, vasoconstrictors can participate in drug interactions that potentially are harmful to patients. Use of antibiotics is an integral part of dental practice. While these agents are generally considered safe in the dental setting, their use may result in interactions with other drugs that patients are taking for various medical conditions.The use of local anaesthetics, sedatives or anxiolytic drugs in combination with other central nervous system depressants or in combination with drugs that inhibit their metabolism can be associated with serious adverse drug interactions. Methods: An electronic search of all literature published until December 2017, was made in Medline/Pubmed and specific web pages devoted to dentistry. Results: Potentially serious adverse drug interactions involving adrenergic vasoconstrictors and antibioticscan occur in dental practice. In most circumstances, careful administration of small doses of vasoconstrictors will permit these drugs to be used with no risk.It is particularly important dentists to be aware of the potentially serious interactions of the antibiotics erythromycin, clarithromycin and metronidazolewith other drugs whose metabolism is impaired by these antibiotics.The adverse drug interactions associated with the use of local anaesthetics and oral sedative/anxiolytic agents in general practice vary in significance. Conclusion: An understanding of possible adverse drug interactions in dentistry may help practitioners avoid and prevent complications.

Item Type: Conference or Workshop Item (Lecture)
Subjects: Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Medical Science
Depositing User: Marija Darkovska-Serafimovska
Date Deposited: 11 Apr 2018 08:01
Last Modified: 11 Apr 2018 08:01

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