Nephrotoxicity of NSAIDs and MTX

Yzeiri Havziu, Drita and Hiljadnikova-Bajro, Marija and Kadifkova Panovska, Tanja and Zylbehari, Ljutvi and Gjorgjeska, Biljana (2017) Nephrotoxicity of NSAIDs and MTX. In: 2nd International Scientific Conference of the Faculty of Medical Sciences, 13-14 Oct 2017, Tetovo, Macedonia.

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Abstract

Headache is one of the most common symptoms encountered in the general population as well as in medical practice worldwide. Migraine is the most frequent cause of headache and a common disabling neurological disorder with a serious socio-economical burden. Despite the introduction more than a decade ago of a new class of migraine-specific drugs with superior efficacy, the triptans, NSAIDs remain the most commonly used therapies for the migraine attack. Some are available over the counter and likely to be abused. Nonsteroidal anti-inflammatory drugs (NSAIDs) are capable of inducing a variety of renal function abnormalities. The adverse effects of nonsteroidal anti-inflammatory drugs (NSAIDs) are mediated via inhibition of prostaglandin synthesis by non-specific blocking cycloxygenase, leading to vasoconstriction and reversible mild renal impairment in hypoperfusion. When unopposed, this may lead to acute kidney injury (AKI). Although this presents as AKI, chronic use of NSAIDs may result in chronic kidney disease (CKD). The standard metrics to follow the progression of AKI, like serum creatinine and blood urea levels, are inconvenient and depend on kidney injury. That’s why we must use specific markers for early detection. In the present review,we will follow the levels of specific urinar biomarkers which we can use as signals for early detection of nephrotoxicity. There has not been prespective study for nefrotoxicity of NSAID used in long term by a pacient with chronic pain.

Item Type: Conference or Workshop Item (Lecture)
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Biljana Gorgeska
Date Deposited: 07 Nov 2017 08:50
Last Modified: 07 Nov 2017 08:50
URI: http://eprints.ugd.edu.mk/id/eprint/18346

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