Impact of active female smoking on controlled ovarian stimulation in intracitoplasmic sperm insemination cycles

Petanovski, Zorancho and Dimitrov, Gligor and Aydin, Birol and Hadzi Lega, Makjuli and Sotirovska, Valentina and Suslevski, Damjan and Saltirovski, Stefan and Matevski, Vladimir and Stojkovska, Snezana and Petanovska, Emilija and Savic, Mladen and Balkanov, Trajan (2012) Impact of active female smoking on controlled ovarian stimulation in intracitoplasmic sperm insemination cycles. Medicinski glasnik, Official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, 9 (2). pp. 273-280. ISSN 1840-0132

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Abstract

Aim To examine the impact of smoking among females on controlled ovarian stimulation (COS), at intra-cytoplasmatic sperm injection (ICSI) outcome. Methods A prospective analysis of outcomes of 876 women (fresh, non donor cycles) of which 559 (63.8%) were non-smokers, 317 (36.2%) were smokers, underwent standard COS/ICSI treatment. Results Among smokers, the average time of COS, expressed in days, was significantly longer compared with non-smokers (10.5±2.10 vs. 10±1.90 p<0, 05). There were no registered significant differences in the number of retrieved oocytes, (10.4±6.8 vs10.3±6.9), mature oocytes (8.6±5.8 vs. 8.4±5.9), in the group of non-smokers versus smokers. However, smoking and age have a significant impact of the number of high-quality embryos, i.e. older smokers had a lower number of high-quality transferred embryos (non-smokers ≥ 35 years : smokers ≥ 35 years; 1.9±1.1 vs. 1.6±1). On multiple logistic regresion analysis, factor that had a significantly negative impact of clinical pregnancy was maternal age. Conclusion Smoking among patients entering the COS and ICSI fertilization process had insignificant negative impact on the final outcome of the process resulting in reduced pregnancy rate. The chance for the pregnancy declines with age, but smoking did not significantly influence the outcome. Key words: in vitro fertilisation, high - quality embryos, clinical pregnancy rate

Item Type: Article
Subjects: Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Medical Science
Depositing User: Gligor Dimitrov
Date Deposited: 05 Oct 2017 08:49
Last Modified: 05 Oct 2017 09:28
URI: http://eprints.ugd.edu.mk/id/eprint/18228

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