Serum determination of 99m Technetium radiolabeled Tirofiban using high performance liquid chromatography in the animal rat model of introduced acute deep venous thrombosis

Darkovska-Serafimovska, Marija and Janevik-Ivanovska, Emilija and Gjorgoski, Icko and Arsova-Sarafinovska, Zorica and Balkanov, Trajan and Ugresic, Nenad (2016) Serum determination of 99m Technetium radiolabeled Tirofiban using high performance liquid chromatography in the animal rat model of introduced acute deep venous thrombosis. In: 18th European Symposium on Radiopharmacy and Radiopharmaceuticals, 7-10 Apr 2016, Salzburg, Austria.

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Official URL: https://link.springer.com/article/10.1186/s41181-0...

Abstract

The development of radiolabeled small peptide or peptidomimetic ligands can bind platelets and their specific expressed receptor have been suggested as a new approach to detect the clot location and, more essentially, to determine the age and morphology of the evolving thrombus. This new approach is focused on the use of a series of radiolabeled platelet GPIIb/IIIa receptor antagonists. Tirofiban N-(butylsulfonyl)- 4-O-(4-(4-piperidyl)-L-tyrosine is a non-peptide tyrosine derivate. The aim of the study was to introduce radioactive-labeled tirofiban as a specific imaging agent for acute DVT and to determine the serum concentrations in normotensive male Wister rats with and without deep acute venous thrombosis in order to confirm the animal model of acute venous thrombosis.

Item Type: Conference or Workshop Item (Poster)
Subjects: Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Divisions: Faculty of Medical Science
Depositing User: Marija Darkovska-Serafimovska
Date Deposited: 01 Sep 2017 09:48
Last Modified: 01 Sep 2017 09:48
URI: http://eprints.ugd.edu.mk/id/eprint/18162

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