Micronucleus Assay as Genotoxicity Method to Determine the Human Health Risk

Velickova, Nevenka and Milev, Mishko (2017) Micronucleus Assay as Genotoxicity Method to Determine the Human Health Risk. International Journal of Current Research in Chemistry and Pharmaceutical Sciences, 4 (5). pp. 31-35. ISSN p-2348-5213, e-2348-5221

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Medical personnel are often occupationally exposed to chronic ionizing radiation (IR). It is known that IR may have damaging effects on chromosomes and genes. The aim of this study was to evaluate the genotoxicity of IR on medical personnel using the micronucleus assay (cytokinesis-block MN) as genotoxicity method and to determine the human health risk. In this study we observed that medical personnel (with long time of exposer of IR) have a increasing the incidence of micronuclei (MNi) (average 16 MN per 1000 binuclear lymphocites). According to our results we concluded that the micronucleus assay determined that all of them have a high risk of professional disease and cancer. This study has a practical importance because it indicates the necessity of introducing a permanent genotoxicological and other type of monitoring of medical personnel exposed to IR and suggests the need of application of different cytogenetic methods and genotoxicological test (like MN assay) that can confirm the chromosome rearrangements. Keywords: Cancer, Cytokinesis-block MN, Ionizing radiation, Lymphocites, Medical personnel

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Divisions: Faculty of Medical Science
Depositing User: Nevenka Velickova
Date Deposited: 14 Aug 2017 13:01
Last Modified: 14 Aug 2017 13:01
URI: http://eprints.ugd.edu.mk/id/eprint/18052

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