Lipophilicity of Peptide Anions: An Experimental Data Set for Lipophilicity Calculations

Gulaboski, Rubin and Scholz, Fritz (2003) Lipophilicity of Peptide Anions: An Experimental Data Set for Lipophilicity Calculations. The Journal of Physical Chemistry B, 107 (23). pp. 5650-5657. ISSN 1520-6106

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Official URL: http://dx.doi.org/10.1021/jp034387e

Abstract

For the first time, the standard Gibbs energies of the transfer of peptide anions from aqueous solution to nitrobenzene were determined with the help of electrochemical measurements. These systematic studies clearly show that the lipohilicity contributions of single amino acid residues to the overall lipohilicity of a peptide anion strongly depend on the position of the amino acid in the backbone of the peptide. Therefore, additive models to calculate the overall lipophilicity of a peptide cannot provide very precise data. The present study is a plea for the experimental establishment of a data set that takes into account the individual nature of an amino acid residue and its position in a peptide.

Item Type: Article
Uncontrolled Keywords: ion transfer, peptides, anions, liquid liquid interface, drug design, themrodynamics of ion transfer, voltammetry
Subjects: Medical and Health Sciences > Basic medicine
Natural sciences > Biological sciences
Natural sciences > Chemical sciences
Natural sciences > Physical sciences
Divisions: Faculty of Agriculture
Depositing User: Rubin Gulaboski
Date Deposited: 31 Oct 2012 13:16
Last Modified: 31 Oct 2012 13:16
URI: http://eprints.ugd.edu.mk/id/eprint/165

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