Standard partition coefficients of anionic drugs in the n-octanol/water system determined by voltammetry at three-phase electrodes

Bouchard, Géraldine and Galland, Alexandra and Carrupt, Pierre-Alain and Gulaboski, Rubin and Mirceski, Valentin and Scholz, Fritz and Girault, Hubert H. (2003) Standard partition coefficients of anionic drugs in the n-octanol/water system determined by voltammetry at three-phase electrodes. Physical Chemistry Chemical Physics, 5 (17). p. 3748. ISSN 1463-9076

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Official URL: http://dx.doi.org/10.1039/b304113a

Abstract

The anionic forms of 26 drugs and organic model compounds have been extensively explored in the n-octanol/ water system using voltammetry at three-phase electrodes. The objective of this study was to validate the ability of this electrochemical system to give reliable values of lipophilicity for organic ions, as well as to gain more information on the lipophilic behaviour of anions in the n-octanol/water system. Results were used to clarify the solvation mechanisms responsible for ion partitioning and to compare the information obtained in the two solvent systems n-octanol/water and 1,2-dichloroethane/water.

Item Type: Article
Uncontrolled Keywords: ionizable drugs, ion transfer, octanol, liquid-liquid interface, biomimetic membranes, standard Gibbs energy of ion transfer, drug design
Subjects: Medical and Health Sciences > Basic medicine
Natural sciences > Biological sciences
Natural sciences > Chemical sciences
Natural sciences > Physical sciences
Divisions: Faculty of Agriculture
Depositing User: Rubin Gulaboski
Date Deposited: 31 Oct 2012 13:15
Last Modified: 05 Nov 2012 11:09
URI: http://eprints.ugd.edu.mk/id/eprint/161

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